ChemInform Abstract: SYNTHESIS AND CORONARY VASODILATING ACTIVITY OF 2‐SUBSTITUTED ADENOSINES

Abstract

Ausgehend von den 2‐Halogeninosinen (I) werden durch Acetylierung, Chlorierung mit dem Vilsmeier‐Reagens und Aminierung über (II) und (III) die 2‐Halogenadenosine (IV) hergestellt.

Synthesis and Impurity Research of 2-Thioadenosine Monohydrate

“…None of these impurities are commercially available; thus, no preparation methods have been reported. 7 8 9 In this study, four process-related impurities, 6 , 7 , 8 , and 9 , were identified, synthesized, and characterized. Moreover, the key parameters that influenced their formation were also investigated.…”

“…The synthesis of compound 7 was performed according to Marumoto et al's method. 8 The reaction mixture was obtained via the degradation of compound 1 . HPLC was used to monitor the reaction, and the reaction mixture was filtered when the reaction was finished.…”

“…mp: 225.0–228.5°C, anhydrous). 8 1 H NMR (600 MHz, DMSO- d 6 ) δ 8.23 (s, 1H), 7.36 (s, 2H), 5.83 (d, J = 6.0 Hz, 1H), 5.42 (d, J = 6.2 Hz, 1H), 5.18 (d, J = 4.8 Hz, 1H), 5.01 (t, J = 5.6 Hz, 1H), 4.62 (q, J = 5.9 Hz, 1H), 4.15 (q, J = 4.8 Hz, 1H), 3.92 (q, J = 4.1 Hz, 1H), 3.64 (dt, J = 11.7, 4.8 Hz, 1H), 3.59 to 3.48 (m, 1H), 2.47 (s, 3H). 13 C NMR (151 MHz, DMSO- d 6 ) δ 164.3, 155.6, 150.3, 138.9, 117.0, 87.4, 85.5, 73.4, 70.7, 61.7, 13.8.…”