ChemInform Abstract: Synthesis and Pharmacological Profile of New 1,3‐Disubstituted Cyclohexanes as Leukotriene B4 Receptor Antagonists.

Abstract

Synthesis and Pharmacological Profile of New 1,3-Disubstituted Cyclohexanes as Leukotriene B4 Receptor Antagonists.-Novel non-aromatic members of stable leukotriene B4 antagonists such as (VIII) and (IX) are described, in which the conjugated double bond of the natural eicosanoid (X) is replaced by a 1,3-disubstituted cyclohexane ring.-(POUDREL, J. M.; HULLOT, P.; VIDAL, J. P.; GIRARD, J. P.; ROSSI, J. C.; MULLER, A.; BONNE, C.; Bioorg. Med.