ChemInform Abstract: Synthesis and QSAR Studies of Thiosemicarbazides, 1,2,4‐Triazoles, 1,3,4‐Thiadiazoles and 1,3,4‐Oxadiazoles Derivatives as Potential Antibacterial Agents.

Desai, N. C.; Bhavsar, A. M.; Shah, Monic; Saxena, Anil Kumar

doi:10.1002/chin.200833036

Cited by 6 publications

(9 citation statements)

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“…The study reported in this article is in continuation of the previous work aimed at synthesizing bio-active heterocyclic entities (Desai and Desai, 2005;Desai and Undavia, 1998;Desai and Undavia, 1996;Desai and Bhavsar, 2008;Desai and Saxena, 2008;Desai and Baldaniya, 2009). …”

Section: Introductionmentioning

confidence: 76%

Dimeric 2-(2-chlorophenyl)-quinazolin-4-ones as potential antimicrobial agents

et al. 2011

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3-(Aryl)-2-(2-chlorophenyl)-6-{2-[2-(2-chlorophenyl)-4-oxo(3-hydroquinazolin-3yl)]ethyl}-3-hydroquinazolin-4-ones had been selected as target bio-active molecules. Several quinazoline derivatives were prepared by using anthranilic acid, acid chloride, 2-amino-ethanol, and different amines. Newly synthesized compounds were screened for their antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger, and Aspergillus clavatus. The compounds 5e, 5g, and 5h are shown to have excellent activity, while 5c, 5d, 5i, 5k, 5l are shown to have very good activity against several strains of bacteria. The structures of the synthesized compounds were firmly established by well-defined spectral analysis techniques like IR, 1 H-NMR, 13 C-NMR, and Mass spectra.

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Section: Introductionmentioning

confidence: 76%

Dimeric 2-(2-chlorophenyl)-quinazolin-4-ones as potential antimicrobial agents

et al. 2011

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“…A mixture of compound (1) (0.01 mole) and (0.02 mole) of phenyl isothiocyanate in ethanol absolute was heated under reflux. After 1hr the reaction mixture was cooled and the solid product was collected and recrystallized from ethanol [6,7].…”

Section: Preparation Of N-phenyl-2-(2-(3-phenyl Thioureido)benzoyl) Hmentioning

confidence: 99%

“…H 2 SO 4 and stirred for 1hr then poured onto crushed ice. The resulting solid was recrystallized from ethanol [6,7].…”

Section: Preparation Of 1-phenyl -3-(2-(5-(phenyl Amino)-1 3 4-thiamentioning

confidence: 99%

“…Heating was continued for 5hr with reflux and the mixture was cooled and poured onto ice-cold water. The resulting solid was washed with water and recrystallized from ethanol [6,7].…”

Section: Preparation Of 1-phenyl -3-(2-(5-(phenyl Amino)-1 3 4-oxadmentioning

confidence: 99%

“…The efficiency of azoles as chemotherapeutic agents is well studied. For example pyrazole and pyrazolone derivatives exhibit antibacterial, antifungal [1,2] and Cox inhibition activity [3] while oxadiazole, thiadiazole and triazole derivatives are widely used for medicinal [4][5][6][7] and industrial purposes [8] like azoles, quinazoline derivatives showed therapeutic effects because of their antihistaminic [9], analgesic and antiinflammatory activities [10] Recently, quinazoles and quinazolines were tested as a good immune modulators [11]. Schiff bases have also been widely reported biologically active due to the toxophoric C=N linkage in them [12].…”

Section: Introductionmentioning

confidence: 99%

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