ChemInform Abstract: SYNTHESIS AND RING‐OPENING REACTIONS OF FUNCTIONALIZED SULTINES. NEW APPROACH TO SPARSOMYCIN

Abstract

Die Cystein‐Derivate (IIa) werden nach Reduktion zu den Alkoholen (IIb) durch Umsetzung mit N‐Chlorsuccinimid (NCS) in Essigsäure in die Sultine (III) übergeführt.

Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity

“…The absolute configuration of the sulfoxide diastereoisomers was determined by CD spectra using documented method. [22][23][24][25][26] The synthesis of cyclic peptide 16 was described in Fig 3. The linear peptide precursors H-(Boc)Lys-pTyr(OBzl)-Ach-Asn-Val-2-Cl-Trt resin were synthesized by Fmoc SPPS. After the peptides were cleaved from resin, the head-to-tail macrocyclization of the linear peptide was achieved successfully using HATU as the coupling reagent and HOAt as the accelerator 27 and then deprotected with the TFA-TIS-H 2 O cocktail.…”