ChemInform Abstract: Synthesis and S‐Methylation of 2‐Thioxopyrido(3′,2′:4,5)thieno(3,2‐d) pyrimidin‐4(3H)‐ones with and without a Phase Transfer Catalyst.

Abstract

Synthesis and S-Methylation of 2-Thioxopyrido(3',2':4,5)thieno(3,2d) pyrimidin-4(3H)-ones with and without a Phase Transfer Catalyst. -A series of new pyridothienopyrimidines (III) (14 examples) are prepared by cyclocondensation of 2-ethoxycarbonyl-3-aminothienopyridines (I) with isothiocyanates with the objective to study their pharmacological properties. The S-methylation of the title compounds (III) is significantly more efficient in the presence of a phase transfer catalyst. -(DAVE, C. G.; SHAH, A. B.; SHAH, H. C.; J. Heterocycl. Chem. 34 (1997) 3, 937-940; Chem. Sci. Lab., Loyola Cent. Res. Dev., St. Xavier's Coll., Ahmedabad 380 009, India; EN)