ChemInform Abstract: SYNTHESIS AND STRUCTURE OF COMPLEXES OF 4‐CYCLOHEXYLAMINOANTHRA(1,2‐C)(1,2,5)SELENODIAZOLA‐6,11‐DIONE WITH GALLIUM CHLORIDE

Зайцев, Б. Е.; Zaitseva, V. A.; Rudnitskaya, O. V.; Gorelik, M. V.; Molodkin, A. K.

doi:10.1002/chin.197711289

Cited by 1 publication

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“…Note that introduction of Fe(III) ions to the solution containing quinone Q" did not lead to any changes in absorption spectra. The stability constant, determined by the molar relations method, was found to be similar to that of Ga ions bound to -pyridoanthraquinone (Zaitsev et al, 1979).…”

Section: Discussionmentioning

confidence: 73%

“…The value of K was (7 ± 1) X 1018 M~3. Note that for complex of Ga with -pyridoanthraquinone in benzene the stability constant K is equal to 1.7 X 105 M™1 (stoichiometry 1:1) (Zaitsev et al, 1979). For comparison of the stability constant obtained by us for Fe(Q^)3 with that for GaQ assume that K\…”

Section: Resultsmentioning

confidence: 98%

“…It was supposed that coordinating atoms in the Fe(Adr)3 complex are oxygen C-ll and oxygen C-12 of adriamycin (Eliot et al, 1984). Proceeding from the structure and donor properties of Q¡?, by analogy with the a-pyridoanthraquinone complex with Ga (Zaitsev et al, 1979), one can suppose that the coordinating ligands in the Q¡? -Fe (III) complex are also the oxygen of the carbonyl group and the nitrogen of the pyridine ring.…”

Section: Discussionmentioning

confidence: 99%

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Role of quinone-iron(III) interaction in NADPH-dependent enzymic generation of hydroxyl radicals

Dikalov

Rumyantseva²,

Пискунов³

et al. 1992

Biochemistry

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To study the effect of chelation of iron ions by quinones on the generation of OH radicals in biological redox systems, we have synthesized quinones that can form complexes with Fe(III) ions: 2-phenyl-4-(butylamino)naphtho[2,3-h]quinoline-7,12-dione (Qbc) and 2-phenyl-4-(octylamino)naphtho[2,3-h]quinoline-7,12-dione (Qoc). A quinone with a similar structure without chelating group was synthesized as a control sample: 2-phenyl-5-nitronaphtho[2,3-g]indole-6,11-dione (Qn). Using optical spectroscopy, we determined the stability constant of Qbc with Fe(III) [Ks = (7 +/- 1) x 10(18) M-3] and the stoichiometry of the complex Fe(Qbc)3 in chloroform solutions. One-electron reduction potentials of Qbc, Qn, and adriamycin in dimethyl sulfoxide were measured by cyclic voltammetry. In the presence of Fe(III) the one-electron reduction potentials shifted toward positive values by 0.16 and 0.1 V for Qbc and adriamycin, respectively. Using the spin trap 5,5'-dimethyl-1-pyroline N-oxide (DMPO) and EPR, it was found that Qbc in the Fe(III) complex stimulated the formation of OH radicals in the enzymatic system consisting of NADPH and NADPH-cytochrome P-450 reductase more efficiently than adriamycin and quinone Qn. This is indicated by the absence of a lag period in the spin adduct appearance for Qbc and by a significantly higher rate of the spin adduct production, as well as by a larger absolute concentration of the spin adduct obtained for Qbc in comparison with Qn in the presence of Fe(III).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 98%