ChemInform Abstract: Synthesis and α‐Adrenergic Binding Ligand Affinities of 2‐Iminoimidazolidine Derivatives.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis of New Imidazolidine and Tetrahydropyrimidine Derivatives

“…Imidazolidines (tetrahydroimidazoles) are important building blocks in biologically active compounds [1] and carriers of pharmacologically active carbonyl compounds [2]. They have been reported to have important biological activities including, for example, 2-[(arylmethoxy) imino]imidazolidines as potential -adrenergic receptor agonist [3], bisimidazolidines and 1,3-disubstituted imidazolidines as antimicrobial [4], 5-(4-chloro or fluoro-benzylidene-3-(4-nitrebenzyl)-4-thioxo-imidazolidin-2-one as antiparasitic [5], sulfonyliminoimidazolidines as oral hypoglycaemic [6], imidazolidin-2,4-diones, 2-thioxoimidazolidin-4-ones, 5-cycloalkylidene-hydantoins, and 5-cycloalkylidene-thiohydantoins as antiarrhythmic and anticonvulsant [7,8], 1,3-dibenzyl-2-arylimidazolidine as anti-inflammatory [9], N,N -di-aryl-methyl-2-(4-diethylamino phenyl) tetrahydroimidazoles and N,N -di-4-diethylamino benzyl-2-(aryl) tetrahydroimidazoles as analgesic [10].…”

CdII-Mediated Efficient Synthesis and Complexation of Asymmetric Tetra-(2-pyridine)-Substituted Imidazolidine

“…The rapid and facile construction of structurally diverse imidazolidines via changing its substituted groups is very important in various fields, mainly deriving from the following considerations: (i) imidazolidines can act as intermediate in the nucleotide biosynthesis, and some metal complexes are confirmed to have good activity as cytotoxic metallopharmaceuticals. − (ii) They are also significant building blocks, meanwhile, in bioactive compounds and carriers of the carbonyl compounds with pharmacological activity, and some of metal complexes are potential chemotherapeutic agents for DNA cleavage. − (iii) Moreover, their transition-metal complexes were widely studied in the field of organic light-emitting diode (OLEDs), , etc.…”