ChemInform Abstract: Synthesis, Asymmetric Aldol Reactions, and X‐Ray Crystallography of Some Oxadiazinanone Derivatives.

Abstract

Other 6-membered heterocycles R 0670Synthesis, Asymmetric Aldol Reactions, and X-Ray Crystallography of Some Oxadiazinanone Derivatives. -Oxadiazinanones (V), synthesized from norephedrine, can be successfully employed in asymmetric aldol reactions. "non-Evans" syn-adducts (IX) (13 examples) are obtained with 76-98% d.e. Hydrolysis varies with the nature of the nitrogen substituent. -(HITCHCOCK*, S. R.; DAVIS, R. A.; RICHMOND, D. M.; DORE, D. D.; KUSCHEL, S. L.; VAUGHN, J. F.; WOLFE, J. A.; HAMAKER, C. G.; CASPER, D. M.; DINGLE, J.; J. Heterocycl. Chem. 45 (2008) 5, 1265-1274; Dep. Chem., Ill. State Univ., Normal, IL 61790, USA; Eng.) -D. Singer 06-175