ChemInform Abstract: Synthesis, Characterization and CNS Activity of Some Novel Piperazine Derivatives.

Abstract

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Synthesis of Glucosylguanidinohydrazones under Microwave Promotion and Ultrasound Irradiation

“…According to other literature, 9 added AcOH will prompt the formation bond of C=N. Contrarily in our work, the guanidinohydrazones can be only obtained in the absence of AcOH and the condensation of glucosyl-aminoguanidines with 3-formylchromone proceed rapidly in boiling THF in a higher yield.…”

Simple and Efficient Copper(I)‐Catalyzed Access to Three Versatile Aminocoumarin‐Based Scaffolds using Isocyanoacetate

“…[11] It involves the reaction of 2-aminopyridine, salicylaldehyde and ethyl isocyanoacetate, and is catalyzed by scandium triflate to afford 3-aminoimidazoA C H T U N G T R E N N U N G [1,2-a]pyridines in good yields (> 80%). However, we accidentally found that by using CuA C H T U N G T R E N N U N G (OTf) 2 as catalyst in this reaction, one strong fluorescent spot was observed in thin layer chromatography (TLC) analysis. Single crystal X-ray diffraction analysis then showed this compound to be 3-formamidocoumarin (Figure 1), obtained in 33% yield (entry 1, Table 1).…”

“…Coumarin and its derivatives occur widely in medicinal chemistry, and are considered to be "privileged structures" in the pharmaceutical and agrochemical industries. [1] A particularly interesting group of coumarins is 3-aminocoumarins, since they are used as CNS depressant, [2] antitumor, [3] anti-inflammatory, [4] and antimicrobial agents. [5] In addition, these compounds are also known to exhibit interesting photochemical behavior and have been used as fluorescent markers.…”

Synthesis and Antimicrobial Screening of 2"-Amino-4"-[2-(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridine -3-yl]-6"-Aryl-4"-H-Pyran-3"-Carbonitrile

“…A large number of substituted imidazo [1,2-a]pyridine derivatives are prepared and tested for varieties of biological activities such as, Antifungal [1][2][3] , Antiallergic 4 , Analgesic 5 , Antagonist 6,7 , Antitumor 8 , CNS active agent 9 , Cytotoxic 10 , Inhibitors of cell proliferation 11 , Gastric acid secretion inhibitor 12 , Antimicrobial 13 , Hypolipidemic 14 , Antipyretic 15 etc. In view of getting to synthesized imidazo[1,2-a] pyridines derivatives and evaluated for their antimicrobial activity.…”