In this mini-review, we have compiled our research group's prior efforts aimed at developing potential, novel and safe antimicrobial agents with improved efficiency by using the hybrid molecular approach on quinoline hybrids. Present mini-review article deals with landscaping of quinoline based bioactive analogues with pyrazoles, thiazoles, 4-thiazolidinones, pyrimidines and 2-pyridones heterocycles. Quinoline motifs containing hybrids with two or more fold antimicrobial activity are described hereby. We have reported a mini review of 174 compounds prepared in our laboratory. The SAR of the most promising compounds is also discussed.