ChemInform Abstract: Synthesis of 1‐Substituted 2‐(Trifluoromethyl)indoles via a Palladium‐Catalyzed Double Amination Reaction.

Abstract

Synthesis of 1-Substituted 2-(Trifluoromethyl)indoles via a Palladium-Catalyzed Double Amination Reaction. -The new, practical process starts from o-halophenyl--substituted substrates (I) and (IV) and allows the formation of 2 C-N bonds in one pot. -(DONG, S.-X.; ZHANG*, X.-G.; LIU, Q.; TANG, R.-Y.; ZHONG, P.; LI, J.-H.; Synthesis 2010, 9, 1521-1525,