ChemInform Abstract: Synthesis of 2,2′‐Diselenobisbenzamides and 4,4′‐Diselenobisbutyramides with Sulfamoyl Groups as New Potential Virucides and Cytokine Inducers.

Abstract

2001 organo-selenium compounds organo-selenium compounds S 0130 32 -178 Synthesis of 2,2'-Diselenobisbenzamides and 4,4'-Diselenobisbutyramides with Sulfamoyl Groups as New Potential Virucides and Cytokine Inducers. -A simple synthesis of the title compounds (III) (9 examples) and (VII) (5 examples) based on the direct acylation of 4-aminobenzenesulfonamides (II) with corresponding chlorocarbonyls (I) or (VI), resp., is developed. Some of the diselenides prepared show strong antiviral effects or induce tumor necrosis factor production. -(PALUS, J.; KLOC, K.; MLOCHOWSKI, J.; MALYSA, P.; SZCZUREK, M.; PIASECKI, E.; RYBKA, K.; Pol.