ChemInform Abstract: Synthesis of 2,3,4‐Tri‐Substituted 3,4‐Dihydroquinazolines via Tandem Nucleophilic Addition/Epoxy Ring‐Opening Cyclization Methodology Using N‐(2‐Oxiranylphenyl)carbodiimides with Nucleophiles.

Abstract

A variety of dihydroquinazolines are obtained diastereoselectively by reaction of carbodiimides (IX) with different O-, S-, N-and C-nucleophiles. An alternative reaction pathway is observed in several cases leading to derivatives (XII) and (XIV). -(SAITO*, T.; OTE, T.; SHIOTANI, M.; KATAOKA, H.; OTANI, T.; KUTSUMURA, N.; Heterocycles 82 (2010) 1, 305-311, http://dx.doi.org/10.3987/com-10-s(e)66 ; Dep. Chem., Fac. Sci., Sci. Univ. Tokyo, Shinjuku, Tokyo 162, Japan; Eng.) -R. Staver