ChemInform Abstract: Synthesis of 2‐Aminoimidazole Marine Metabolites: Clathrodine (X) and 3′‐Amino‐1′‐(2‐aminoimidazol‐4(5)‐yl)‐prop‐1′‐ene (XIII).

Daninos, Sandra; Al‐Mourabit, Ali; Ahond, A.; Zurita, M. Bedoya; Poupat, C.; Potìer, Pierre

doi:10.1002/chin.199449273

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2009

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“…Hassner was the first to report the reaction of imidazole lithium with a vinyl azide, hydrolysis of the intermediate triazine gives the aminoimidazole [57]. Since that report, Potier has popularized the use of lithiated imidazoles [58]. Potier reported that lithiation with LDA followed by azide transfer from TsN 3 efficiently generated the 2-azidoimidazoles ( Fig.…”

Section: Direct Introduction Of N2mentioning

confidence: 99%

2-Aminoimidazoles from Leucetta Sponges: Synthesis and Biology of an Important Pharmacophore

Sullivan¹,

Giles²,

Looper³

2009

CBC

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This review will focus on the ability of the 2-aminoimidazole to occupy a unique subset of chemical space which makes it an ideal pharmacophore for the development of small molecule collections for discovery based research. These observations rely both on the use of 2-aminoimidazoles as building blocks in medicinal chemistry as well as the recent discovery of alkaloids from sponges of the genus Leucetta which exhibit a diverse range of biological activities around a relatively limited structural core. The preparation of these compounds will also be highlighted.

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Section: Direct Introduction Of N2mentioning

confidence: 99%