ChemInform Abstract: SYNTHESIS OF 2‐METHYL‐3‐ARYL‐ OR ‐ARYLALKYL‐5,6‐DIMETHYL‐ OR ‐POLYMETHYLENETHIENO(2,3‐D)PYRIMIDIN‐4‐ONES

Abstract

Die Umsetzung der Acetamidothiophencarbonsäuren (I) mit Acetanhydrid (II) liefert die Thienooxazine (III), die mit den primären Aminen (IV) zu Thienopyrimidonen (V) reagieren.

Microwave-Assisted and Conventional Synthesis of Benzothieno [3,2-e] [1,3,4] triazolo[4,3-c]pyrimidines: A Comparative Study

“…1−5 For instance, a number of thienopyrimidines are known to possess antimalerial, antiallergic, hypocholesterolemic, analgesic, anti-inflammatory, diuretic, CNS depressant and antiviral activities. 6,7 In view of these fascinating and encouraging results and in continuation of our work on biologically active nitrogen and sulfur heterocycles, 8 we have synthesized some thienopyrimidine and triazolothienopyrimidine derivatives. Addition to the conventional method the microwave irradiation technique has also been employed for the synthesis of some thienopyrimidines (2,3,4) and triazolothienopyrimidines (5a−c) and the results have been compared.…”

The Synergy of Combined Use of DMSO and Bronsted Acid (Ionic Liquid) as a Catalyst Part I: Efficient Niementowski Synthesis of Modified Quinazolinones

“…Purine bases and their bioisoteric analogs were widely used as building block in combinatorial chemistry. The bioisoteres of purine bases such as thienopyrimidine and pyridopyrimidine possess wide range of biological activity such as PDE inhibitory activity, antiparkinsonism, CNS depressant, analgesic, antiinflammatory [17][18][19] etc. Since Niementowski's preparation of 4(3H)-quinazolinone by fusing anthranilic acid with formamide [20], several methods aimed toward the synthesis of modified quinazolinones have been pursued [21,22].…”