ChemInform Abstract: Synthesis of 3‐Aryl‐4‐methyl‐1,2‐benzenedisulfonimides, New Chiral Broensted Acids. A Combined Experimental and Theoretical Study.

Barbero, Margherita; Bazzi, Stefano; Cadamuro, Silvano; Bari, Lorenzo Di; Dughera, Stefano; Ghigo, Giovanni; Padula, Daniele; Tabasso, Silvia

doi:10.1002/chin.201149127

Search citation statements

Order By: Relevance

Paper Sections

Select...

Results1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compounds 2 and 3 are expected to racemize easily because of the lack of steric hindering. At least to some extent, stereochemical inertness may be expected for compound 1 [25]. Electronic circular dichroism spectra were used to reveal a possible enantiomeric excess for compounds 1-3, but in no case could we measure any significant sig-▶ Fig.…”

Section: Resultsmentioning

confidence: 99%

LC-MS- and NMR-Guided Isolation of Monoterpene Dimers from Cultivated Thymus vulgaris Varico 3 Hybrid and Their Antityrosinase Activity

et al. 2019

View full text Add to dashboard Cite

Targeted isolation based on a combination of NMR and HPLC-PDA-MS of a dichloromethane extract of Thymus vulgaris Varico 3 aerial parts afforded one new p-cymene dimer, 6,3′,4′-trihydroxy-5,5′-diisopropyl-2,2′-dimethylbiphenyl (1), together with two known p-cymene derivatives (2 and 3), as well as five known compounds, namely, thymol (4), oleanolic acid (5), ursolic acid (6), cirsimaritin (7), and xanthomicrol (8). The structural elucidation of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR, and HRESIMS experiments. The biphenyls were assayed for their inhibitory activity on tyrosinase. Compounds 2 and 3 showed negligible activity on tyrosinase, while compound 1 effectively inhibited the enzyme with 35% (± 0.3) inhibitory activity, higher than the inhibition of the reference compound kojic acid (18.6 ± 0.02).

show abstract

Section: Resultsmentioning

confidence: 99%