ChemInform Abstract: Synthesis of 4‐(3H)‐Quinazolinones by Microwave Assisted Tandem Reaction and Evaluation of Their Antibacterial and Antifungal Activities.

In the title compound, C14H9BrN2O, the quinazoline unit is essentially planar, with a mean deviation of 0.058 (2) Å from the least-squares plane defined by the ten constituent ring atoms. The dihedral angle between the mean plane of the quinazoline ring system and the 4-bromophenyl ring is 47.6 (1)°. In the crystal, molecules are linked by intermolecular C—H⋯N and C—H⋯O hydrogen bonds, forming infinite chains of alternating R 2 2(6) dimers and R 2 2(14) ring motifs.

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“…For the synthesis of the title compound, see: Priya, Zulykama et al (2011). For a related structure, see: Priya, Srinivasan et al (2011).…”

Section: Related Literaturementioning

confidence: 99%

3-(4-Bromophenyl)quinazolin-4(3H)-one

et al. 2011

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“…TS and DV thank the TBI, X-ray facility, CAS in Crystallography and Biophysics, University of Madras, India, for the data collection and a DST inspire fellowship for financial support (Wolfe et al,1990), anti-inflammatory (Tereshima et al,1995), anti-HIV (Pandeya et al, 1999). In addition to that, the quinazolinones exibit anti-bacterial and anti-bacterial and anti-fungal activities (Priya et al, 2011).…”

Section: Methodsmentioning

confidence: 99%

“…For the synthesis of the title compound, see: Priya et al (2011). For related structures, see: Li & Feng (2009); Li et al (2010).…”

Section: Related Literaturementioning

confidence: 99%

3-(4-Chlorophenyl)quinazolin-4(3H)-one

Priya

Srinivasan

Girija³

et al. 2011

Acta Cryst E

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In the title compound, C14H9ClN2O, the quinazoline unit is essentially planar, with a mean deviation from the least-squares plane defined by the ten constituent ring atoms of 0.027 (2) Å. The dihedral angle between the mean plane of the quinazoline ring system and the 4-chlorophenyl ring is 44.63 (5)°. In the crystal, molecules are linked by intermolecular C—H⋯N and C—H⋯O hydrogen bonds, forming infinite chains of alternating R22(6) dimers and R22(14) ring motifs.

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“…All the quinazolinone compounds were screened for their In vitro anti fungal activity against Candida Albicans, Aspergilles Niger. Some of these compounds showed good antifungal activity than reference drug [21].…”

Section: Compound 5a-bmentioning

confidence: 99%

A Review on a Highly Important Hetrocycle Quinazolinone Compounds and their Diverse Biological Activities

2016

European Reviews of Chemical Research

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Quinazolinone and their derivatives have been studied extensively for various biological activities such as anti-inflammatory, antimicrobial, anticancer, anticonvulsant and anti-HIV activity etc. The purpose of this review was to collate literature work reported by researchers on quinazoline for their various pharmacological activities. Quinazolinone derivatives are one of the most active classes of compounds possessing a wide spectrum of biological activity. Recently several scientists have been reported that introduction of various heterocyclic moieties at quinazolinone nucleus modulate the activity. Various derivatives of quinazolinone have been synthesized and evaluated for their biological activities. This review might be helpful in the development of these novel lead molecules to potential drug candidates for future prospect.Keywords: Quinazoline, antimicrobial, Anti HIV, Anti cancer, biologically active. IntroductionHeterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, heterocyclic structures form the basis of many pharmaceutical, agrochemical and veterinary products. Quinazoline (1) are classes of fused heterocycles that are of considerable interest because of the diverse range of their biological activities such as, antimicrobial, anticancer, anticonvulsant, anti-tubercular, etc [1][2][3][4][5]. Quinazolin is a heterocyclic compound consists of two fused six membered simple aromatic rings, a benzene ring and a pyrimidine ring. The quinazolin nucleus has attracted the attention of medicinal chemists due to its well known anticancer activity, and many substituted quinazolin derivatives have recently earned great interest in chemotherapy as antitumor drugs [6]. Pharmacologically quinazolin particularly quinazolin-4-one (2) or quinazolinone are the most important classes of heterocyclic compounds. Quinazolin-4-one is synthesized when the keto group is introduced in the pyrimidine ring of quinazolin. Quinazolinone compounds possess versatile biological activities; such as anticancer [7][8]

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ChemInform Abstract: Synthesis of 4‐(3H)‐Quinazolinones by Microwave Assisted Tandem Reaction and Evaluation of Their Antibacterial and Antifungal Activities.

Abstract: A one‐pot synthesis of quinazolinone derivatives (IV) (10 examples) from anthranilic acid, primary aromatic amines and Vilsmeier reagent is developed.

Cited by 8 publications

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3-(4-Bromophenyl)quinazolin-4(3H)-one

3-(4-Bromophenyl)quinazolin-4(3H)-one

3-(4-Chlorophenyl)quinazolin-4(3H)-one

A Review on a Highly Important Hetrocycle Quinazolinone Compounds and their Diverse Biological Activities

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