ChemInform Abstract: Synthesis of 5‐Arylidene‐2,4‐thiazolidinediones by Knoevenagel Condensation Catalyzed by Baker′s Yeast.

Abstract

Synthesis of 5-Arylidene-2,4-thiazolidinediones by Knoevenagel Condensation Catalyzed by Baker's Yeast. -Baker's yeast offers an eco-friendly protocol for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds. The thiazolidinediones (VI) are precursors of hypoglycemic agents. -(PRATAP, U. R.; JAWALE, D. V.; WAGHMARE, R. A.; LINGAMPALLE, D. L.; MANE*, R. A.; New J. Chem. 35 (2011) 1, 49-51, http://dx.doi.org/10.1039/c0nj00691b ; Dep. Chem., Marathwada Univ., Aurangabad 431 004, India; Eng.) -Kieslich 17-023

Visible light induced Knoevenagel condensation: A clean and efficient protocol using aqueous fruit extract of tamarindus indica as catalyst

“…In addition, Knoevenagel condensation products exhibit inhibition of antiphosphorylation of EGF-receptor and antiproliferative activity [9]. Due to their importance from a pharmacological, industrial and synthetic point of view a large number of methods for the Knoevenagel condensation have been reported using various Lewis acids/bases [10][11][12][13][14], microwave assisted reaction [15][16][17], ultrasound irradiation [18,19], biotechnology-based approach [20,21], solid phase [22,23], ionic liquid [24][25][26] or using green solvent like water [27][28][29], and grindstone method under solvent-free condition [30][31][32]. It is noteworthy to observe that all these protocols have some drawbacks, such as use of expensive catalyst, high thermal conditions, disposal of toxic solvents and catalyst, long reaction time often pose a problem.…”