ChemInform Abstract: Synthesis of 6‐Formyl Derivatives of 5,8‐Dimethoxycarbostyryl.

Abstract

Synthesis of 6-Formyl Derivatives of 5,8-Dimethoxycarbostyryl. -In connection with a research on antitumor heterocyclic quinones bearing the 2,5,8-quinolinetrione moiety, 6-formyl quinolones are required as intermediates. The first route involves the oxidation of the 6-methylcarbostyryl derivative (IV), the second gives the aldehyde (VIII) via direct formylation of the dimethoxycarbostyryl (VI). -(UBEDA, J. I.; AVENDANO, C.; MENENDEZ, J. C.; VILLACAMPA, M.; Heterocycles 38 (1994) 12, 2677-2689; Dep. Quim. Org.