ChemInform Abstract: Synthesis of 7‐Aryl‐1,8‐naphthyridines via Addition of Aryl Boronic Acids to 1,8‐Naphthyridine N‐Oxides.

Abstract

Synthesis of 7-Aryl-1,8-naphthyridines via Addition of Aryl Boronic Acids to 1,8-Naphthyridine N-Oxides. -The method is not sensitive to moisture or air and can be extended to other electron-deficient N-oxides [cf. (XII), (XIV) and (XVI)] with a different success. The process can further be applied to the synthesis of 6,7-diaryl--1,8-naphthyridines when 6-halosubstituted substrates such as (VII) are employed. -(BENNIE, L. S.; BURTON, P. M.; MORRIS*, J. A.; Tetrahedron Lett. 52 (2011) 37, 4799-4802, http://dx.