ChemInform Abstract: Synthesis of an Aminoisoxazolidine‐Substituted Quinolone Acid.

Abstract

(R)‐Cycloserine (I) is converted into the protected aminoisoxazolidine (VIII) which reacts with the trifluorooxoquinolinecarboxylic acid (XI), prepared from pentafluorobenzyl alcohol (IX), to produce a mixture of the isoxazolidinyl derivative (XII) and the amine (XIII).