ChemInform Abstract: SYNTHESIS OF CYCLIC HYDROXAMIC ACIDS

Abstract

Die N‐Hydroxy‐pyridone (I)‐(III) werden aus den entsprechenden Pyridonen (IV) durch Oxidation mit Natriumwolfra mat /H202 erhalten.

Synthesis and study of antihelminthic activity of new 2-pyridone derivatives

“…The process in an anhydrous medium probably proceeds via acetylation of the nitrile group of pyridones Ia-Ic with the formation of an intermediate imidate B [5]. Hydrolysis of the nitrile group ofpyridone Ia to amide is confirmed by data reported in [2]. The principal possibility of the synthesis of N-substituted pyrrolidonium perchlorates IIa -IIc from amides was proved by the synthesis of salt IId via cyclization of 3-butylaminocarbinylpyridone (121) obtained by amination of6-methyl-lH-furo [3, 4-…”

“…Nitriding of pyridone Ia with concentrated nitric acid in acetic anhydride yields a I 5-nitro derivative [2]. R Perchloric acid is widely used in the la-Ic synthesis of nitrogen-containing heterocycles [3].…”

“…Both control and test animals were killed 7 -8 days after the drug's administration and the number of helminths localized in the region of small intestine was determined. The efficiency of the drug preparations was evaluated as the percentage of escaped helminths in the test animals with respect to the control [2].…”

“…As is known, 4-alkoxymethyl-3-cyarto-2(1H)-pyridones are polyfunctional compounds that may behave differently under the action of acids: the structures of reaction products depend both on the nature of acid and its concentration [1,2]. For example, 4-alkoxymethyl-3-cyano-2(1H)-pyridones are readily hydrolyzed in the solutions of a 50% sulfilric acid and concentrated hydrochloric acid with the formation of 2(5H)-furanones annelated with 2(1H)-pyridone [1].…”

“…its conversion into the corresponding perchlorates IIa -IIc as a result of intramolecular alkylation of the amide nitrogen atom [2]. The process in an anhydrous medium probably proceeds via acetylation of the nitrile group of pyridones Ia-Ic with the formation of an intermediate imidate B [5].…”