ChemInform Abstract: Synthesis of Diverse 6‐Oxa‐allocolchicinoids by a Suzuki—Miyaura Coupling, Acid‐Catalyzed Intramolecular Transacetalization Strategy.

Abstract

Synthesis of Diverse 6-Oxa-allocolchicinoids by a Suzuki-Miyaura Coupling, Acid-Catalyzed Intramolecular Transacetalization Strategy. -(YADAV, D. B.; TALELI, L.; VAN DER WESTHUYZEN, A. E.; FERNANDES, M. A.; DRAGOUN, M.; PROKOP, A.; SCHMALZ, H.-G.; DE KONING, C. B.; VAN OTTERLO*, W. A. L.; Eur. J. Org. Chem. 2015, 23, 5167-5182, http://dx.doi.org/10.1002/ejoc.201500573 ; Mol. Sci. Inst., Sch. Chem., Univ. Witwatersrand, Johannesburg 2050, S. Afr.; Eng.) -H. Hoennerscheid 51-172

Synthesis of Dichlorophosphinenickel(II) Compounds and Their Catalytic Activity in Suzuki Cross-Coupling Reactions: A Simple Air-Free Experiment for Inorganic Chemistry Laboratory

“…Therefore, attention from recent research has been focused on the incorporation of an inexpensive and abundant first-row transition metal such as Ni, Fe, Cu, and Co. 8 Suzuki cross-coupling between organoboron compounds and organohalides is the most common reaction for a C−C bond formation, 9 which has been widely utilized in the pharmaceutical industry. 10 Unfortunately, the reactions are typically catalyzed by expensive Pd catalysts. For example, mesitylboronic acid and iodobenzene undergo a C−C cross-coupling reaction in a presence of Pd(PPh 3 ) 4 and a strong base to produce the biaryl product A in excellent yield under mild reaction conditions (Scheme 1).…”