ChemInform Abstract: Synthesis of Eight‐Membered Cyclic Thiophosphorous Acids.

Synthesis of organophosphorus derivatives of 2,6‐di‐tert‐butyl‐4‐methylphenol

“…Phosphorus derivatives of 2,6-di-tert-butyl-4-methylphenol (ionol) are effective antioxidants and promising ligands. However, the methods for synthesis of such compounds are rather complicated and require rigid conditions [2][3][4][5][6]. In this work, we propose convenient procedures for synthesis of a series of ionol phosphorus derivatives with one, two, or three phosphorus-containing groups, starting from the readily accessible 3,5-di-tert-butyl-4-hydroxybenzaldehyde 1 prepared by the procedure described in [7] and trimethylsilyl esters of trivalent phosphorus acids, which are well known as unique organophosphorus synthons [8][9][10].…”