Abstract:The asymmetric synthesis of ent-ketorfanol from simple and commercially available precursors is reported. A Rh I -catalyzed intramolecular CÀHa lkenylation/torquoselective 6p electrocyclization cascade provides afused bicyclic 1,2-dihydropyridine as ak ey intermediate.C omputational studies were performed to understand the high torquoselectivity of the key 6p electrocyclization. The computational results demonstrate that ac onformational effect is responsible for the observed selectivity.T he ketone functional… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.