ChemInform Abstract: Synthesis of New Dibenzo[b,f]azepine Derivatives

5-(Prop-2-ynyl)-5H-dibenzo[b,f]azepine

“…For the biological activities of iminostilbene, see: Kumar & Naik (2010); Balaure et al (2009) ;Bhatt & Patel (2005); Fuenfschilling et al (2005); Rosowsky et al (2004); Brzozowski & Saczewski (2002); Kulkarni et al (1991); Arya et al (1977). For the crystal structures of the closely related compounds, see: Jayasankar et al (2009) ;Nagaraj et al (2005); Sadashiva et al (2005).…”

“…For the crystal structures of the closely related compounds, see: Jayasankar et al (2009) ;Nagaraj et al (2005); Sadashiva et al (2005). Data collection: SMART (Bruker, 2000); cell refinement: SAINT (Bruker, 2000); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL, PARST (Nardelli, 1995) and PLATON (Spek, 2009 (Balaure et al, 2009), oxazepine (Fuenfschilling et al, 2005) and imipramine (Bhatt & Patel, 2005). The structural analogue of iminostilbene showed a wide range of biological activities such as antioxidant (Kumar & Naik, 2010), antihypertensive (Arya et al, 1977), antitumor (Brzozowski & Saczewski, 2002), pesticidal (Kulkarni et al, 1991), and DHFR inhibitory activity (Rosowsky et al, 2004).…”

Friedel-Crafts chemistry. Part 40. An expedient novel synthesis of some dibenz-azepines, -azocines, 11H-benzo[f]pyrido[2,3-b]azepines and 6H-benzo[g]pyrido[2,3-c]azocines

“…, 221 (18), 206 (35), 191 (21), 178 (41), 166 (24), 151 (17), 109 (33), 104 (15), 90 (12), 76 (8). Anal.…”

“…[11][12][13][14] These polycyclic compounds are also identified as vital structural constituents useful intermediates in organic synthesis. [15][16][17] Moreover, they exhibit diverse medical functions as antidepressant, antiviral, antiepileptic, antiseizure, anticonvulsant, antimicrobial, antimalarial, anticancer, antioxidant antitumor, antibiotics and sirtuin-2 inhibitory activities. [18][19][20] Full literature survey for the applied methodologies in the synthesis of 5H-dibenz[b,f]azepine, dihydrodibenzazepine and tetrahydro-5H-dibenz[b,f]azocine systems revealed that synthesis of such heterocycles has been a prominent research objective for over a century and a variety of well established methods have been developed to access 5H-dibenzo[b,f]azepine derivatives.…”

Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine

“…Moreover, in 2009 Balaure et al documented heterocyclic analogs of dibenzoazepine urea 4-5 ( Figure 1), which were found to be potent psycologically active compounds [14]. Previously Martinez group reported a library of benzamide analogs of dibenzazepine [15], which were found to exhibit antidepressant as well as tranquilizer activity.…”