ChemInform Abstract: Synthesis of New Mannich Bases Derived from 5‐Phenyl‐1,3,4‐oxadiazole‐2‐thione and Investigation of the Conformational Isomers of Dimethyl 5‐(5‐Phenyl‐2‐thioxo‐1,3,4‐oxadiazole‐3‐methylamino)isophthalate.

Abstract

1,3,4-oxadiazole-3-methylamino)isophthalate. -(ROMAN, G.; AGACHE*, C.; MANCIULEA, I.; COMANITA, E.; DUMITRESCU, L.; Rev. Roum. Chim. 52 (2007) 12, 1103-1110; Dep. Wood Technol., Transilvania Univ., RO-500036 Brasov, Rom.; Eng.) -H. Toeppel

Optimizing the interaction between a new complex of platinum and copper with immunoproteins

“…15drops of HCl was added slightly to salt to release the 1,3,4-Oxadiazole product (Pollak and Stanovnik, 1965). Last step and according Mannich reaction the ligand was synthesized by adding 5 mL of piprydine and 15 mL of formaldehyde to the solution of 0.001 mole 0.28 g from 1,3,4 Oxadiazole in methanol, the mixture was refluxed at 75 o C for 3 h. A precipitate was separated out and washed with acetone and dried at room temperature (Roman et al, 2007).…”

Synthesis and characterization of 5-aryl-1,3,4-oxadiazole-2(3h)thione derivatives

“…Pharmacological screening of several 2-(acetylamino)-5-alkyl-1,3,4-oxadiazoles revealed their spasmolytic and potent hypotensive action.2,5-Disubstituted 1,3,4-oxadiazole derivatives were shown to be promising hypoglycemic agents able to reduce the level of blood glucose when administered at an oral dose of 100mg/kg. A structureactivity relationship study towards the inhibition of monoamine oxidase A involved a series of tricyclics bearing oxadiazole moieties [4].…”