ChemInform Abstract: Synthesis of New Spirooxindole Derivatives Through 1,3‐Dipolar Cycloaddition of Azomethine Ylides and Their Antitubercular Activity.

Abstract

Synthesis of New Spirooxindole Derivatives Through 1,3-Dipolar Cycloaddition of Azomethine Ylides and Their Antitubercular Activity. -Non-stabilized azomethine ylides, generated in situ from isatin (II) or quinone (VI) and L-proline (III), are reacted with bis(arylidene)indan-2-ones (I) as dipolarophiles in a 1,3-dipolar cycloaddition. Novel dispiroheterocyclic compounds (IV)/(V) and (VIII) are obtained in low to good diastereoselectivity. Some of these spirocyclic compounds exhibit high antitubercular activities. -(ROUATBI, F.; ASKRI*, M.; NANA, F.; KIRSCH, G.; SRIRAM, D.; YOGEESWARI, P.; Tetrahedron Lett. 57 (2016) 2, 163-167, http://dx.