ChemInform Abstract: SYNTHESIS OF NITROSOPYRIDINOLS BY THE CYCLOCONDENSATION OF ISONITROSO‐β‐DICARBONYL COMPOUNDS WITH CYANOACETAMIDE

Zeolites in the Synthesis of 1-Alkyl-2-oxonicotinonitriles

“…They are constituents of plant growth regulators, herbicides, and defoliants for they are modulators of chlorophyll biosynthesis in plants [3].2-Oxonicotinonitriles IIV are commonly prepared by the cyclocondensation of cyanoacetamide or its N-alkyl derivatives with acetylacetone [4] or 3-hydroxyiminopenta-2,4-dione [5]. The condensation of 3-hydroxyiminopenta-2,4-dione with cyanoacetamide in the presence of NaA zeolite furnished 4,6-dimethyl-5-nitroso-2-oxonicotinonitrile.…”

“…2-Oxonicotinonitriles IIV are commonly prepared by the cyclocondensation of cyanoacetamide or its N-alkyl derivatives with acetylacetone [4] or 3-hydroxyiminopenta-2,4-dione [5]. The reaction is carried out either in a buffer solution at pH 9.1 [6] or in the presence of catalysts.…”

“…The conversion was determined from the optical density at the wavelength in the region 600 700 nm using the known value of e equal to 3925 for 4,6-dimethyl-5-nitroso-2-oxonicotinonitrile prepared along procedure [5]. The conversion was determined from the optical density at the wavelength in the region 600 700 nm using the known value of e equal to 3925 for 4,6-dimethyl-5-nitroso-2-oxonicotinonitrile prepared along procedure [5].…”