ChemInform Abstract: Synthesis of Novel Triheterocyclic Thiazoles as Antiinflammatory and Analgesic Agents.

Kalkhambkar, Rajesh G.; Kulkarni, Geeta M.; Shivkumar, H.; Rao, Rekha

doi:10.1002/chin.200809139

Cited by 6 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The triheterocyclic thiazoles containing coumarin and carbostyril(1azacoumarin) (41) were evaluated for their analgesic and anti-inflammatory activities. The 7-chloro substitution in carbostyril and 6,8-dibromo substitution in the coumarin ring improved anti-inflammatory activity (Kalkhambkar et al, 2007). A series of N-aryl substituted 2-imino-2H-1benzopyran-3-carboxamides and 2-oxo-2H-1benzopyran-3-carboxamides were screened for antiinflammatory activity in albino rats.…”

Section: Anti-inflammatory and Analgesic Activitymentioning

confidence: 99%

Pharmacologically potentials of different substituted coumarin derivatives

Int¹

2019

Preprint

View full text Add to dashboard Cite

Coumarin and its derivatives are widely spread in nature. Coumarin goes to a group as benzopyrones, which consists of a benzene ring connected to a pyrone moiety. Coumarins displayed a broad range of pharmacologically useful profile. Coumarins are considered as a promising group of bioactive compounds that exhibited a wide range of biological activities like anti-microbial, anti-viral, antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer, anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensive activities etc. The coumarin compounds have immense interest due to their diverse pharmacological properties. In particular, these biological activities make coumarin compounds more attractive and testing as novel therapeutic compounds.Capsule Summary: Coumarin derivatives are considered as promising bioactive compounds that exhibited a wide range of biological activities.Cite This Article As: M. Asif. Pharmacologically potentials of different substituted coumarin derivatives. Chemistry

show abstract

Section: Anti-inflammatory and Analgesic Activitymentioning

confidence: 99%

Pharmacologically potentials of different substituted coumarin derivatives

Int¹

2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Natural products containing various heterocyclic skeletons and diverse bioactivities are important sources in drug discovery. [1][2][3][4][5][6] Coumarin (2H-1-benzopyran-2-one), a heterocyclic compound with fused phenolic benzene and α-pyrone rings, possessed various bioactivities including anti-microbial, [7][8][9][10] anti-viral, [11][12][13][14] anticancer, [15][16][17][18][19][20] anti-oxidant, [21][22][23] anti-coagulation, [24][25][26][27][28] anti-diabetic, [29][30][31][32] anti-inflammatory [33][34][35] and neuroprotective [36][37][38] activities, which offered them great potential for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Daphnetin, a Coumarin in Genus Stellera Chamaejasme Linn: Chemistry, Bioactivity and Therapeutic Potential

Hang

Wang

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

Coumarins is a huge family of phenolic compounds containing a common structure of 2H-1-benzopyran-2one. Nowadays, more than 1,300 natural-based coumarins have been identified in a variety of plants, bacteria and fungi, many of them exhibited promising biomedical performance. Daphnetin (7,8-dihydroxycoumarin), a typical coumarin, showed a couple of bioactivities such as anti-cancer, antibacterial, anti-inflammatory and antiarthritis. In the treatment of diseases, it has been verified that daphnetin has outstanding therapeutic effects on diabetes, arthritis, transplant rejection, cancer and even on central nervous system diseases. In China, it is being used for clinical applications, about 93 patent publications were associated with daphnetin. Due to its wide therapeutic potentials in clinical applications, numerous research on the action mechanisms and synthetic methods of daphnetin have been performed to support the future developments. Herein, we summarized the chemical synthetic methodologies, bioactivities, therapeutic potentials and structure-activity relationships of daphnetin and its derivatives. Moreover, the state-of-the-arts in current daphnetin study and future perspective in this field were discussed. Hopefully, this review would be beneficial for the discovery of new coumarin-based biomedicine in the near future.

show abstract

“…Thiazoles and their derivatives possess a wide range of biological activity. As a platform for drug development they can be successfully used for the treatment of allergies [1,2], hypertension [3], inflammation [4,5], schizophrenia [6], hypnotics [7], analgesia [8][9][10], HIV infections [11][12][13] and cancer [14][15][16][17][18][19].…”

mentioning

confidence: 99%

QSAR studies and antimicrobial potential of 1,3-thiazolylphosphonium salts

Trush¹,

Kovalishyn²,

Blagodatnyi³

2016

Ukr.Biochem.J.

View full text Add to dashboard Cite

The regression QSAR models were built to predict the antimicrobial activity of new thiazole derivatives. Compounds with high predicting activity were synthesized and evaluated against Gram-positive and Gram-negative bacteria and fungi. 1,3-Thiazole-4-ylphosphonium salts 4 and 5 displayed good antibacterial properties and high antifungal activity. The predictions are in a good agreement with the experiment results, which indicate the good predictive power of the created QSAR models.

show abstract

ChemInform Abstract: Synthesis of Novel Triheterocyclic Thiazoles as Antiinflammatory and Analgesic Agents.

Cited by 6 publications

References 1 publication

Pharmacologically potentials of different substituted coumarin derivatives

Pharmacologically potentials of different substituted coumarin derivatives

Daphnetin, a Coumarin in Genus Stellera Chamaejasme Linn: Chemistry, Bioactivity and Therapeutic Potential

QSAR studies and antimicrobial potential of 1,3-thiazolylphosphonium salts

Contact Info

Product

Resources

About