ChemInform Abstract: Synthesis of Oxygen‐Containing Heterocyclic ortho‐Dinitriles Based on 4‐Bromo‐5‐nitrophthalonitrile.

Abstract

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New Nitrogen-Containing Five-Membered Heterocyclic ortho-Dicarbonitriles for Preparation of Macroheterocycles

“…Despite the progress made recently in this field, alternative methods of synthesizing these compounds continue to be developed. First of all, it should be noted that S N Ar-reactions occurring with the participation of 4-nitro-and 4-bromo-5-nitrophthalonitrile under homo-and hetero-conditions allow the study of the synthesis of a large number of diverse aromatic and heterocyclic compounds, [17][18][19][20][21][22][23] and related compounds that are condensed with the phthalonitrile fragment (Scheme1). In addition, we have developed methods for the synthesis of 3-substituted 2-amino-1-hydroxy-1H-indole-5,6-dicarbonitriles (2), [24] and 2-aryl-1-Hydroxy-1H-indole-5,6-dicarbonitriles (3), [25] based on 4-bromo-5-nitrophthalonitrile (1) (Scheme 2).…”