ChemInform Abstract: Synthesis of Polyamine Alkaloids by the Condensation of a Chiral β‐Lactam with a Cyclic Imino Ether. (S)‐Dihydroperiphylline and Its Derivatives.

Abstract

Synthesis of Polyamine Alkaloids by the Condensation of a Chiral β-Lactam with a Cyclic Imino Ether. (S)-Dihydroperiphylline and ItsDerivatives.-A facile route for the synthesis of (S)-dihydroperiphylline (Va) and its analogues (Vb) and (Vc) utilizing the condensation of chiral lactam (II) with a cyclic imino ether of a 9-membered lactam (III) and following reductive ring expansion as the key reactions is described. -(MATSUYAMA,