ChemInform Abstract: SYNTHESIS OF POLYHYDROXYFAVONOL METHYL ETHERS WITH POTENTIAL CYCLOTOXIC ACTIVITY. I. SYNTHESIS OF QUERCETAGETIN AND GOSSYPETIN DIMETHYL ETHERS FOR THE STRUCTURE DETERMINATION OF NEW FLAVONOLS FROM PARTHENIUM, CHRYSOSPLENUM, LARREA, AND SPINACIA SPECIES

Wagner, Hildebert; Maurer, I.; Farkas, L.; Strelisky, J.

doi:10.1002/chin.197737309

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1), as described in the Material and Methods, and were identified, in turn, as betulin (3) [14], betulinic acid (4) [14], 5,7-dihydroxy-3,6,4¢-trimethoxyflavone (5) [15], 23-hydroxyursolic acid (6) [10], oleanolic acid (7) [16], tricin (8) [11], ursolic acid (9) [6], ferulic acid (10) [12], (+)-1-hydroxypinoresinol (11) [8], prinsepiol (12) [13], and 5,7,3¢-trihydroxy-4¢-methoxyflavone (13) [9], by comparison of their physical and spectroscopic data (m. p., [a] D , 1 H-NMR, 13 C-NMR, DEPT, 2D NMR, and MS) with those reported in the literature. Original Paper tent with three degrees of unsaturation.…”

Section: Resultsmentioning

confidence: 99%

Antitubercular Constituents ofValeriana laxiflora

Wang

Franzblau

et al. 2004

Planta med

View full text Add to dashboard Cite

Antitubercular bioassay-guided fractionation of the n-hexane- and CH (2)Cl (2)-soluble extracts of the above-ground biomass and roots of Valeriana laxiflora led to the isolation of a new iridolactone, (4R,5R,7S,8S,9S)-7-hydroxy-8-hydroxymethyl-4-methyl-perhydrocyclopenta[ c]pyran-1-one ( 1), and a new lignan, (+)-1-hydroxy-2,6-bis- epi-pinoresinol ( 2), along with eleven known compounds, betulin ( 3), betulinic acid ( 4), 5,7-dihydroxy-3,6,4'-trimethoxyflavone ( 5), 23-hydroxyursolic acid ( 6), oleanolic acid ( 7), tricin ( 8), ursolic acid ( 9), ferulic acid, (+)-1-hydroxypinoresinol, prinsepiol, and 5,7,3'-trihydroxy-4'-methoxyflavone. The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic evidence. The absolute stereochemistry of 1 was determined by chemical transformations and Mosher ester procedures. In a microplate alamar blue assay against Mycobacterium tuberculosis, compounds 2 - 9 exhibited minimum inhibitory concentrations (MIC) of 15.5 - 127 microg/mL, while the other isolates were regarded as inactive (MIC > 128 microg/mL). In addition, all the isolates were tested for cytotoxicity against African green monkey Vero cells in order to evaluate their selectivity potential.

show abstract