ChemInform Abstract: Synthesis of Potent Anticancer Thieno[2,3‐d]pyrimidine Derivatives.

Abstract

VIIIb) exhibit significant cytotoxicity against the human colon carcinoma cell line HCT 116 and are more potent than imatinib. -(KANDEEL, M. M.; MOUNIR, A. A.; REFAAT*, H. M.; KASSAB, A. E.; J. Chem. Res. 36 (2012) 5, 266-275, http://dx.doi.org/10.3184/174751912x13333849411283 ; Dep. Org. Chem., Fac. Pharm., Cairo Univ., Kasr El-Aini 11562, Cairo, Egypt; Eng.) -K. Woydowski 42-171

2-Amino-4-arylthiophene-3-carbonitrile and Formamidine Acetate as Key Building Units for the Synthesis of 5-Arylthieno[2,3-d]pyrimidin-4- amines

“…Thieno [2,3-d]pyrimidines, bicyclic systems with three heteroatoms, comprise a thiophene ring fused with the pyrimidine moiety [1]. The thieno [2,3-d]pyrimidine skeleton an important class of bioactive heterocycles, which has shown broad pharmaceutical and biological activities such as anti-in ammatory (A) [2], antibacterial (B) [3][4][5], antimicrobial (C) [6], anticancer (D) [7][8][9], antimalarial (E) [10], anti-leukemic (F) [11], anti-tumor (G) [12,13], antioxidant (H) [14], and antiviral agents (I) (Fig. 1) [15].…”