ChemInform Abstract: Synthesis of Ptaeroxylin (Desoxykarenin): An Unusual Chromone from the Sneezewood Tree Ptaeroxylon obliquum.

Abstract

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Natural Compounds with Oxepinochromene Scaffold. Structure, Source, Biological Activity and Synthesis

“…Moody et al [137,138] . described total synthesis of eranthin 32 , ptaeroxylin 41 and ptaeroxylinol 42 , based on the combined key Claisen rearrangement – ring closing metathesis (RCM) protocol.…”

“…Moody et al [137,138] described total synthesis of eranthin 32, ptaeroxylin 41 and ptaeroxylinol 42, based on the combined key Claisen rearrangementring closing metathesis (RCM) protocol. Noreugenin 91 [139] Following the Moody's protocol, Malefo et al [61] synthesized obliquumol (12-O-acetyleranthin) 39 (Figure 5) and 12-O-acetylptaeroxylinol 43 (Figure 6) with the additional acetylation of eranthin 32 and ptaeroxylinol 42, respectively, with acetyl chloride (Schemes 8 and 9) in mild yields.…”

Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives

“…This scaffold arises only in a small set of bioactive natural products produced by plants (Figure 4) [18][19][20][21]. (refluxing toluene), large excess of amine (up to 10 eq.)…”

A Concise and Efficient Total Synthesis of α-Mangostin and β-Mangostin from Garcinia Mangostana

“…In order to obtain compound 13, we tried many solvents such as dimethylbenzene, N, N-dimethylaniline and diphenyloxide. Finally N, N-dimethylaniline was identified to be suitable for this reaction and compound 13 was prepared in 87% yield [17]. The successful synthesis of 13 raised the possibility of constructing the isopentene groups at C-2 and C-8 of the xanthone skeleton.…”