ChemInform Abstract: Synthesis of Pyridines by Carbenoid‐Mediated Ring Opening of 2H‐Azirines.

Abstract

A novel strategy of activation of 2H‐aziridines provides a broad range of highly conjugated poly‐arylpyridine systems by formal [3 + 3]‐cycloaddition.

Synthesis of 2H-Azirines via Iodine-Mediated Oxidative Cyclization of Enamines

“…Owing to the high reactivity enhanced by the ring strain, they can participate in many chemical transformations 1 as nucleophiles, electrophiles, dienophiles, or dipolarophiles. As valuable synthons, 2Hazirines have been extensively utilized to construct other heterocyclic skeletons such as indoles, 2 pyrroles, 3 pyridines, 4 oxazoles, 5 pyrazines, 6 triazoles, 7 and azepines. 8 Moreover, this structural motif also occurs frequently in natural products 9 with diverse biological properties.…”