ChemInform Abstract: Synthesis of Small and Medium Size Monocyclic Hydroxamic Acids

Trapencieris, Pēteris; Strazdina, J.; Bertrand, Philìppe

doi:10.1002/chin.201302194

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2019

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“…Biological properties and therapeutic applications of hydroxamic acids have been reported in many recent review articles [31,32], but there is no review article dedicated to the synthesis of hydroxamic acids sofar, except a short review article, which was published while we were finalizing this manuscript [33]. Monocyclic hydroxamic acids and siderophore based hydroxamic acids have been reported in many reviews recently [34][35][36][37][38]. These hydroxamic acid derivatives are beyond the scope of this review article.…”

Section: Introductionmentioning

confidence: 99%

Methods for Hydroxamic Acid Synthesis

Alam

2019

COC

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Substituted hydroxamic acid is one of the most extensively studied pharmacophores because of their ability to chelate biologically important metal ions to modulate various enzymes, such as HDACs, urease, metallopeptidase, and carbonic anhydrase. Syntheses and biological studies of various classes of hydroxamic acid derivatives have been reported in numerous research articles in recent years but this is the first review article dedicated to their synthetic methods and their application for the synthesis of these novel molecules. In this review article, commercially available reagents and preparation of hydroxylamine donating reagents have also been described.

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