ChemInform Abstract: SYNTHESIS OF SOME 1,3,4‐THIADIAZOLES OF POSSIBLE ANTIMICROBIAL ACTIVITY

Abstract

Die 2‐Hydrazino‐thiadiazole (I) werden in Ethanol oder Pyridin zu den Monoacylierungsprodukten (III), in Dioxan zu den zweifach acylierten Derivaten (IV) umgesetzt.

A New Type of Synthesis of 1,2,3‐Thiadiazole and 1,2,3‐Diazaphosphole Derivatives Via‐Hurd‐Mori Cyclization

“…D-(+)-camphor, di-methoxy acetophenone p-bromo acetophenone, p-nitro acetophenone p-amino acetophenone were obtained from Fluka or Aldrich. (6,7,8,9,10) A mixture of Camphor (1, 0.95 equivalent) or 3,4-dimethoxy acetophenone (2, 0.95 equivalent) or P-bromoacetophenone (3, 0.95 equivalent) or p-nitro acetophenone (4, 0.95 equivalent) or p-amino acetophenone (5, 0.95 equivalent), respectively and thiosemicarbazide (1.00 equivalent) was dissolved in absolute ethanol (30 ml). The mixture was heated for 5 hr.…”

“…Derivatives of 1,2,3-thiadiazoles and 1,2,3-diazaphosphole are known to exhibit antiinflammatory [1][2][3] , antiviral 4,5 , analgesic 6,7 , antimicrobial [8][9][10][11][12] , anticonvulsant [13][14][15][16] and antidepressant activity. 17 Among the pharmacological profiles of 1,2,3-thiadiazoles and 1,2,3-diazaphospholes, their antimicrobial, anticonvulsant and antidepressant properties seem to be the best documented.…”

Synthesis of New PMB‐Substituted Indoles Containing 1,3,4‐Oxadiazole and 1,2,4‐Triazole Units

“…They are also applied in agriculture as herbicides, fungicides, or insecticides [20,21]. As a closely related class of compounds, 1,2,4-triazole derivatives are known to exhibit anti-inflammatory [22,23], antiviral [24], analgesic [25], antimicrobial [26][27][28], anticonvulsant [29], and antidepressant activity [30]. Combination of the oxadiazole or triazole motifs with the indole nucleus may enhance these activities.…”