Abstract:Synthesis of Some Piperazinylpyrazolo [3,4-b]pyridines as Selective Serotonin Re-Uptake Inhibitors.-Starting from 2,6-difluoropyridine (I), a number of piperazinylpyrazolo[3,4-b]pyridines (IX) and (X) are synthesized by directed ortho metallation and sequential intra-and intermolecular displacement of fluorine. The products are tested for their activities as selective serotonin re-uptake inhibitors. Compounds (IX) prove to be the most potent in the series and show a similar selectivity as fluoxetine. -(SHUTSKE… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.