ChemInform Abstract: Synthesis of Substituted Triazolyl Curcumin Mimics that Inhibit RANKL‐Induced Osteoclastogenesis.

Abstract

Synthesis of Substituted Triazolyl Curcumin Mimics that Inhibit RANKL--Induced Osteoclastogenesis. -Cu-catalyzed Huisgen 1,3-cycloaddition reaction between azidoarenes (I) and various alkynes leads to the title compounds (III) (22 examples). In particular, curcumin mimics (IIIc), (IIIg) and (IIIh) strongly inhibit osteoclast differentiation. -(PARK, S.-K.; OH, S.; SHIN, H. K.; KIM, S. H.; HAM, J.; SONG, J.-S.; LEE*, S.; Bioorg. Med. Chem. Lett. 21 (2011) 12, 3573-3577, http://dx.