ChemInform Abstract: Synthesis of the Enantiomers of the Hypolipidaemic Agent 2‐(4‐(2,2‐ Dichlorocyclopropyl)phenoxy)‐2‐methylpropanoic Acid (Ciprofibrate).

Abstract

Synthesis of the Enantiomers of the Hypolipidaemic Agent 2-(4-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropanoic Acid (Ciprofibrate).-The synthesis of the enantiomers of the title compound (IV), a potent, long-acting hypolipidaemic agent, in 99% e.e. is achieved via resolution of racemic (I) using (+)-or (-)-tartaric acid. Conversion of the resolved cyclopropylaniline into the chiral phenol (II) proceeds without racemization. -(BAXTER, M. P.; CARR, G.; ELLAMES, G. J.; HERBERT, J. M.; MAN-SOUR, G. A.; NAZIR, M. A.; SAINDANE, M. T.; SMITH, D. I.; VOJVODIC, P. R.; J. Chem.