ChemInform Abstract: Synthesis of the 6‐C‐Methyl and 6‐C‐(Hydroxymethyl) Analogues of N‐Acetylneuraminic Acid and of N‐Acetyl‐2,3‐didehydro‐2‐deoxyneuraminic Acid.

Abstract

To study the effect of substituents on the upper side of the pyranose ring of sialic acids upon the inhibition of neuraminidases, the C2‐branched derivatives (Ib), (IIb) and (IIc) of N‐acetylneuraminic acid (Ia) and its 2,3‐didehydro‐2‐deoxy derivative (IIa) are prepared possessing non‐polar methyl and polar hydroxymethyl groups.