ChemInform Abstract: Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N‐Phosphinylimines Employing La(III)‐TFAA Activation.

Abstract

. -N-Phosphinylimines such as (I) undergo nucleophilic additions such as aza-Friedel-Crafts reactions, aza-ene reactions, tandem aza-Prins/Friedel-Crafts reactions and tandem reactions with 1,3-dienes to give a series of non-cyclized and cyclized products or the bis-indan (XIX). The protected amino group of (VII) can be incorporated into the alkaloid framework (VIII). -(KINOSHITA, H.; INGHAM, O.

Machine Learning-Guided Discovery of New Electrochemical Reactions

“…1 These approaches typically rely on high-throughput experimentation of batch reaction mixtures of a few reactants, with the search domain truncated to reactions with a specific type of catalyst, those with reactants containing a type of desired functionality, or those belonging to a specific mechanistic regime. [2][3][4][5][6][7][8][9][10] In general, reactant selection in these studies are subject to a number of factors, including perceived differences in reactivity, compatibility with a certain mode of catalysis, compatibility with the desired analytical technique, and empirically measured reactivity. Despite the success of many of these studies, such approaches to reaction discovery have not achieved mainstream use, with chemical intuition remaining the primary method of reaction discovery in organic synthesis.…”