ChemInform Abstract: The Biosynthesis of Pramanicin: Origin of the Carbon Skeleton.

Abstract

The Biosynthesis of Pramanicin: Origin of the Carbon Skeleton. -Incorporation of labeled acetates and serine into pramanicin (I) shows that its carbon skeleton is derived from eight acetate units and a serine residue, implying that the biosynthesis proceeds via an acyl-tetramic acid intermediate. -(HARRISON, P. H. M.; HUGHES, D. W.; RIDDOCH, R. W.; Chem. Commun. (Cambridge) (1998) 2, 273-274; Dep. Chem., McMaster Univ., Hamilton, Ont. L8S 4M1, Can.; EN)