ChemInform Abstract: The First Example of 4,7,8,9‐Tetrahydrothieno‐[2,3‐d]azocine Synthesis by Domino Reaction of 4‐Aryl‐4,5,6,7‐tetrahydrothieno[3,2‐c]pyridines with Activated Alkynes.

Abstract

The First Example of 4,7,8,9-Tetrahydrothieno-[2,3-d]azocine Synthesis by Domino Reaction of 4-Aryl-4,5,6,7-tetrahydrothieno[3,2-c]pyridines with Activated Alkynes. -It is shown that the expansion of the tetrahydropyridine fragment requires the presence of an aryl substituent at position 4 of the tetrahydrothieno[3,2-c]pyridines as it stabilizes the intermediate acyclic zwitterion. -(VOSKRESSENSKY*, L. G.; BORISOVA, T. N.; CHERVYAKOVA, T. M.; MATVEEVA, M. D.; GALAKTIONOVA, D. V.; TOLKUNOV, S. V.; TOLKUNOVA, V. S.; ERESKO, A. B.; VARLAMOV, A. V.; Chem. Heterocycl. Compd. (N. Y., NY, U. S.) 50 (2014) 9, 1338-1345, http://dx.