ChemInform Abstract: THE OXIDATION OF UNSYMMETRICAL THIOSULFINATE‐ EVIDENCE FOR α‐DISULFOXIDE AS AN INTERMEDIATE

Ōae, Shigeru; KIM, Y. H.; Takata, Toshikazu; Fukushima, Daikichi

doi:10.1002/chin.197729151

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2006

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“…The initial step would include cyclization of 1,3-bis-alkylsulfanyl-propan-2-ol to produce [1,2]dithiolan-4-ol, which would then be oxidized to 1-oxo-1l 4 ± [1,2]dithiolan-4-ol. Such an oxidation of an unsymmetrical thiosulfinate has been reported previously [26]. The subsequent steps to the thiosulfonate can occur by two conceivable pathways.…”

Section: Resultssupporting

confidence: 68%

Bruguiesulfurol, A New Sulfur Compound fromBruguiera gymnorrhiza

Homhual¹,

Zhang²,

Bunyapraphatsara³

et al. 2006

Planta med

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A new cyclic 4-hydroxy-dithiosulfonate, bruguiesulfurol (1), as well as two known 4-hydroxydithiolane 1-oxides, brugierol (2) and isobrugierol (3) were isolated from the flowers of Bruguiera gymnorrhiza. With stably-transfected HepG2 cells, the three isolates activated antioxidant response element (ARE) luciferase activation with (EC(50)) values of 56.7, 3.7 and 1.8 microM, respectively. Compounds 2 and 3 also inhibited phorbol ester-induced NF-kappaB (nuclear factor-kappaB) luciferase activity with IC (50) values of 85.0 and 14.5 microM, respectively. In addition, compound 2 inhibited enzyme cyclooxygenase-2 (COX-2) activity with an IC(50) value of 6.1 microM. The structures of these isolates were determined by spectral data, and that of compound 1 was confirmed by X-ray crystallographic analysis.

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Section: Resultssupporting

confidence: 68%