ChemInform Abstract: The Pseudo‐Michael Reaction of 1‐Aryl‐4,5‐dihydro‐1H‐imidazol‐2‐amines with Ethyl Ethoxymethylenecyanoacetate.

Abstract

The Pseudo-Michael Reaction of 1-Aryl-4,5-dihydro-1H-imidazol-2-amines with Ethyl Ethoxymethylenecyanoacetate. -The products (III) of the title reaction, on heating in acetic acid, undergo cyclization to 2,3-imidazo[1,2a]pyrimidines (IV) only, whereas on melting, a mixture of compounds (IV) and (VI) is obtained due to transesterification during the chromatographic separation of the compounds (VI). -(KACZOR, A. A.; KIJKOWSKA-MURAK, U.; PIHLAJA, K.; SINKKONEN, J.; WYSOCKI, W.; KARCZMARZYK, Z.; MATOSIUK, D.; Monatsh. Chem. 144 (2013) 8, 1171-1182, http://dx.doi.org/10.1007/s00706-013-0982-y ; Dep. Synth. Chem. Technol., Med. Univ., PL-20-093 Lublin, Pol.; Eng.) -R. Langenstrassen 47-159