ChemInform Abstract: THIACYANOCARBONS. 6. 1,4‐DITHIINO(2,3‐C;6,5‐C′)DIISOTHIAZOLE‐3,7‐DICARBONITRILE, ISOTHIAZOLE(3,4‐F)(1,2,3,4,5)PENTATHIEPINE‐8‐CARBONITRILLE, AND DISODIUM 5‐CYANOISOTHIAZOLEDITHIOLATE

Abstract

Aus dem Tetracyan‐dithiin (I) entstehen mit Sulfiden in Gegenwart von NaI die kondensierten Cyan‐isothiazole (II) und (III).

Synthesis and Identification of Pentathiepin-Based Inhibitors of Sporothrix brasiliensis

“…This was supported by a previous report by DuPont in 1977 [18]. In this program, 7-cyano-7H-(1,2,3,4,5) pentathiepino(6,7-c)pyrazole (5) was developed as a potent anti-fungal in multiple crop species, providing near total control of all fungal growth [18][19][20][21][22][23]. Two of the three main compounds commercially used to suppress fungal growth are the polysulfide-containing compounds selenium sulfide (6) and pyrithione zinc (7), both used for topical applications (used to treat skin and crops respectively) [24][25][26][27].…”

“…The compounds (13,16,(18)(19)(20)(21)(22)(23)(24) were tested using the broth microdilution technique in accordance with the respective reference protocols of the CSLI (Clinical and Laboratory Standards Institute). The reading of the plates was performed in wells with 100% inhibition of fungal growth (all isolates).…”

“…The pentathiepin functionality (5, 9-17) has been utilized for several different indications including neoplastic diseases, Alzheimer's, viruses, cancer, bacteria, mycoses, and as an inhibitor of protein kinase C ( Figure 2) [18][19][20][21][22][23]32,[39][40][41][42][43][44][45][46][47][48][49][50]. The DuPont compound 5 showed promising activity against fungus in plants with broad spectrum activity against a wider range of plant disease [18].…”