ChemInform Abstract: TREND IN NAPHTHALENE ACYLATION BY THE FRIEDEL‐CRAFTS METHOD

Dumpis, M. A.; Kudryashova, N. I.; Khromov‐Borisov, N. V.

doi:10.1002/chin.198109161

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2006

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“…At first, essentially according to Dumpis et al, 6 we prepared the 1-(naphthalen-2-yl)propan-1-one 4 by addition of a solution of naphthalene to propionyl chloride and AlCl 3 in nitrobenzene. As expected, only the desired b regioisomer was obtained.…”

Section: Resultsmentioning

confidence: 99%

Highly diastereoselective synthesis of enantiopure naphthylaminoalcohols with analgesic properties

et al. 2006

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The diastereoselective synthesis via Grignard reaction of enantiopure analgesic naphthylaminoalcohols has been performed. The chiral racemic key intermediate 3-dimethylamino-2-methyl-1-(naphthalen-2-yl)propan-1-one and enantiomers were prepared and transformed into the desired compounds by addition of the organometallic reagent. The chemical characterization of all diastereoisomers was accomplished by 1H NMR and HPLC analyses and the absolute configuration assigned by CD spectroscopy. The in vitro and in vivo profile has also been evaluated.

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Section: Resultsmentioning

confidence: 99%

Highly diastereoselective synthesis of enantiopure naphthylaminoalcohols with analgesic properties

et al. 2006

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ChemInform Abstract: TREND IN NAPHTHALENE ACYLATION BY THE FRIEDEL‐CRAFTS METHOD

Abstract: Friedel‐Crafts‐Acylierungen von Naphthalin (II) mit kurzkettigen aliphatischen Säurehalogeniden liefern in Chloroform überwiegend die α‐Acylnaphthaline (I), in Nitrobenzol überwiegend die β‐Isomeren (III).

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Highly diastereoselective synthesis of enantiopure naphthylaminoalcohols with analgesic properties

Highly diastereoselective synthesis of enantiopure naphthylaminoalcohols with analgesic properties

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