This work reports synthesis of ten novel derivatives of 5-(1-(substituted phenyl)-4,5-diphenyl-1H-imidazol-2-yl)-4-methylthiazole 5(a–o). The reaction of benzil, primary aryl amines, 4-methylthiazole-5-carbaldehyde and ammonium acetate was carried out in one pot in the presence of eco-friendly catalyst Ceric ammonium nitrate in solvent ethanol to give final compounds. The structures of the synthesized compounds were confirmed by spectral characterization such as IR, 1H-NMR, 13C-NMR and mass spectral studies.